Protein and gene names

There are lots of really great protein and gene names out there.  The Drosophila literature has that novelty in spades.  For example, the cheapdate gene makes flies get tipsy easier than your average fly;  methuselah generates flies that live longer than average; lilliputian flies are quite small.  Based on my post doctoral work, I like diaphanous, the deletion of which causes flies to have wings that are transparent.

In the realm of protein names, I think my favorite may be Shugoshin, which binds to and protects cohesin during cell division; shugoshin is the Japanese word for protector or guardian spirit.  While septin and actin were my favorite proteins when I was in the lab, they are not likely to conjure up any interesting imagery.  I suppose actin has inspired several interesting review titles (e.g. Actin up in the nucleus, Actin' like actin?). The other names that I love are those that give the impression of a gerund spoken with a southern accent.  In my reading today, I came across my new favorite protein name: fidgetin, which is a microtubule severing protein. Other protein names that make me giggle: spastin, profilactin, villin, supervillin. 

In doing a bit of research for this post, I learned that while Sega has no problem with the use of Sonic Hedgehog as a gene name, Pokemon threatened to sue if the gene name was not changed.

Of course, the other end of the spectrum exists. The protein p53 is named simply for the apparent molecular weight on SDS-PAGE.  As a graduate student, I worked with MSP, major sperm protein, named so because it was the major component of Ascaris sperm.

While this practice of creative naming may introduce troubles in creating consistency between species, it certainly can help keep scientists entertained while reading papers.  

Here is a nice list of other gene and protein names from Robert Krulwich.

What I've been reading these days: Radioactive by Lauren Redniss and Elephants on Acid by Alex Boese

Since I started working as a Scientific Editor at Elsevier in May, I have found more time for reading for leisure.  I have peppered my reading selections with assorted science writings. First, I quickly plowed through Radioactive: Marie and Pierre Curie: A Tale of Love and Fallout by Lauren Redniss.  Radioactive is a graphic novel that highlights the passion of the Curies for science and for each other.  The book itself was so thoughtfully assembled; for example, the cover glows in the dark, much like Curie's radioactive elements. 

Based on the recommendations of Amazon, I followed up with Elephants on Acid and other Bizarre Experiments by Alex Boese.  Where Radioactive made me long for my old life in the lab, filled with its ups and down and unusual characters, Elephants on Acid was appropriate for my new position as a Scientific Editor. In my evaluation of the papers and the search for appropriate reviewers, I have found myself in some strange corners of PubMed. At one point, I found a paper that examined the effect of LSD to assist in the rehabilitation of alcoholics (Psychedelic Therapy Utilizing LSD in the Treatment of the Alcoholic Patient: A Preliminary Report).  It seems that scientists were very excited about the effects of LSD, thus they tested everything from spiders (The Effect ofLSD-25 on Spider Web Formation) to suburban housewives (see the work of Sidney Cohen).  The titular experiment that tested LSD in elephants was surprisingly repeated by two, independent groups. While the first group seemed to overdose the poor elephant, who subsequently died, the second group found the right dose and reported their observation in the journal Science. 

Boese finds lots of other strange experiments. The ones that I found most interesting were the work of Daniel Simons, which explores the phenomenon of change blindness. These experiments are best watched rather than explained. (http://www.simonslab.com/videos.html)  Other experiments tested questions like: Can people distinguish Coke from Pepsi? Do people get less choosy of whom they will take home from a bar after last call? What does the soul weigh? Of course, the author also explains some rather infamous experiments, including the Stanford Prison Experiment and the Milgram Obedience experiment. However, it is unlikely that experiments like these will cross my desk; rather, I am more likely to see papers that examine the proteomics of horse semen or the effect of vanilla extract (or really anything you can imagine) on cancer cells. 

Torch song or swan song?

In my research into new directions, I have stumbled upon lots of blog posts just like this one (for example, this and this). They all seem to share a sense of loss.  Indeed, one day in the lab I was listening to some sad music, as I am wont to do on a rainy, gray day, when suddenly, I found myself crying and it took me a while to figure out why: I identified my relationship with science with the heart-sick protagonist in the song. 

My friend and lab mate from grad school often compares work at the bench to an abusive relationship: one in which you are constantly beaten down, but are apt to forget about it once you have one good day.  At the bench, that one good day every few weeks has to carry you through all the dark, data-less days.  For some people, that one day is enough, but it does not seem to be enough for me anymore.

For more than twelve years, my quotidian existence has been built around getting up and heading to the bench.  The idea that I won’t be picking up my pipettes anymore seems strange.  Instead, I suppose my day will be filled with reading the literature, checking the science blogs, and writing and editing.   For the time being, I will be working as a freelance scientific editor.  Of course, I will be looking for more traditional jobs in scientific publishing as well.  I hope that this leaves some time for science writing, which is what I started graduate school with the intent of doing.   

I hope that this change will help return my love to me.  In recent months, I have felt the flutter a few times, usually while reading science blogs.  There is certainly lots of great science out there.  Now I hope to find it from the computer rather than at the bench.       


Update Nov 2013: Looks like someone at Nature had the same thoughts: Postdoc's torch song

I am the 80%.

My decision to leave the bench has not been an easy one.  

I have been applying for jobs, and I found myself writing this sentence for my cover letter.  This seems like such a simple sentence.  It feels rather cliché.  It is definitely an understatement.  In reality, the past year has been wrought with tears and anxiety. 

The reason the sentence feels cliché is that it likely is.  The academic bottleneck is a reality that many post docs in science will have to face.  The likelihood of a post doc in the biological sciences landing a job as a PI is pretty low.  In the seventies, 55% of PhD's would have a tenure-track job; in the past decade the number is closer to 20%.   (More cogent articles have addressed this issue, e.g., The PhD problem and The PhD Factory, so I will not belabor the point here.)  Nonetheless, lots and lots of post docs brave the odds and join a lab. What drives PhD's to keep making the leap of faith?  Judging by the behavior of my lab mates, who tirelessly toil away for 60-70 hours a week, it is somewhere between passion and madness.  I recently heard one lab mate, upon being asked what she would do if she weren’t a scientist, reply simply and without a trace of drama, “I would die.”  Is it this simple?  Like an artist or a writer, some people are just called to do this and could not consider an alternative. 

Goodbye bench.

In my case, I feel I was lucky to stumble upon this job in the first place.  As my project comes to a close, I find myself questioning why I ever spent all that time in the lab.  Of course, I was like the others: driven by the pursuit of the answer to my question, in search of the perfect experiment to make the paper that much better.  No matter how sad I get about the fizzle of my project, I try to recall the days when I knew that I could beat the odds and get my own lab and do some really great science.  I am still jealous of those that are living the dream, and I hope that they can make it work.  

For me, I am embarking on a new stage as a science editor and writer. I will be sure to keep this blog updated as I progress.