The Fly Room: a new film about Thomas Hunt Morgan's genetics laboratory

I just discovered the website for the new movie The Fly Room. I could not be more excited to see this film as it combines two of my favorite things: science and cinema. The film is set in Thomas Hunt Morgan's genetics lab at Columbia University. From 1911-1928, Morgan's lab, nicknamed the Fly Room, pioneered the use of fruit flies as a model organism to understand genetics. The lab made several major contributions towards understanding mutations, heredity, and sex-linked traits. Morgan's Fly Room has a unique combination that make it a great subject for a film: an unusual lab space, memorable scientists, and cutting-edge science. (Sam Kean's The Violinist's Thumb does an excellent job of telling this fascinating story in a way that highlights all of these features.)

The lab space has been described as being not much bigger than a broom closet. Archival photos, such as the one above, show benches covered with old milk bottles filled with fruit flies and stuffed with gauze. The lab used bananas to feed the flies, which caused a characteristic fetid odor. It seemed like fruit flies were everywhere, an impression made worse by the small space. Of course, Morgan's habit of squishing non-mutant fruit flies on any available space helped contribute to the mess. The Space Revisited section of the website includes some great movies and details about the process of recreating the unique space for the movie.

The Fly Room at Columbia University - Restored to Its Original State from Imaginal Disc on Vimeo.

The lab also hosted an amazing array of characters. One of these scientists was Calvin Bridges, a handsome genius with an appetite for both science and women. Calvin Bridges was a brilliant scientist, but his philandering damaged his career (Morgan disapproved of his behavior and would not promote him) and cut short his life (Calvin died of syphilis at age 41). After his death, his lab mates burned his personal diaries to protect his reputation.



Alexis Gambis, the film's writer and director, became fascinated with the story of the Fly Room during his PhD in molecular biology at the Rockefeller University. Based on his interest in the story of Calvin Bridges, Gambis sought out Betsey Bridges, the late scientist's daughter. Exchanging stories with Betsey gave Gambis a new way to tell the story of the Morgan lab. The film uses Betsey's visit to the Fly Room as a young girl to explore the girl's relationship with her father as well as the science at the heart of the Morgan lab.

As evidenced by the recent films The Imitation Game and The Theory of Everything, casting scientists as characters in the story of science can create a useful narrative tool. While the focus of these films has been entertainment (indeed, all of these films have taken some degree of poetic license), they also serve as a tool to elucidate the scientific process and inform the public about the importance of basic research. The critical reception of The Fly Room has been very good. I am confident it will show in Boston soon, so I will be sure to update this post when I get to see the film.

More information:
Here is a great story on The Week: Exploring The Fly Room
You can follow The Fly Room on Twitter to see where it is showing next. 

Sources:
Sam Kean's The Violinist's Thumb
Cold Spring Harbor Laboratory library: Morgan's lab

Another great read from Sam Kean - The Violinist's Thumb

Because I enjoyed Sam Kean's Disappearing Spoon, I was excited to start the Violinist's Thumb. This book did not disappoint. I have to admit that I finished this book some time ago and now it is really overdue at the library. Thus, I present some rather unconnected thoughts.

Much like The Disappearing Spoon, this book has lots of fascinating stories. There were several parts of the book that really stuck with me. By far, my favorite was the history of the discovery of DNA. Kean discusses the story of Watson and Crick and all the good stuff (e.g., infighting, competition, and other assorted nastiness) you may have read or seen in The Double Helix, but the book also delves into some other very interesting characters that had major roles in unraveling the function and structure of DNA. One of the many things I loved about being in the lab was the plethora of unusual people that are attracted to that particular line of work. The lab of Thomas Hunt Morgan at Columbia around 1907 certainly attracted its fair share. The so-called "Fly Room" was a very small space with many large personalities that bred fruit flies as well as revolutionary science. Eventually, Morgan's lab lead to major contributions towards our understanding about mutations and heredity as well as sex-linked traits. Of course, his other contribution was the introduction of the fruit fly as a model organism.

The book also focuses on several other important scientists who were integral to our understanding to DNA and inheritance. These scientists included Sister Miriam Michael Stimson, who (like Gregor Mendel) performed science while in service to the church, Lynn Margulis and Barbara McClintock. This chapter, entitled "DNA Vindication", was centered on the important findings that each of these women made. This chapter was also very character-driven; each of these scientists was very much about going against the grain. In the end, I found these stories to be insightful not just about the results, but also about the restrictions on and expectations of women in science. I was glad that not only Rosalind Franklin (the Sylvia Plath of molecular biology) got coverage here!   

Sam Kean has talked about several of the stories in this book on the Radiolab podcast. In the episode entitled Double Blasted, we hear the story of a man who was present in both Hiroshima and Nagasaki when the atomic bombs were dropped. In the episode Inheritance, he discusses some spurious results with midwife toads that led to the downfall of the scientist behind the work, Paul Kammerer. In the same episode, they discuss some really interesting stories about epigenetic modifications, which has completely changed the way we look at genetics. Now it is no longer simply what genes you are passing down to your child. Rather, it can also be about the environmental effects that your ancestors experienced generations ago.

Here are some other highlights:

• The titular story concerns the violinist Paganini, who was allegedly blessed/cursed with a rare joint disease that allowed him to have much great flexibility in this fingers. This allowed him to accomplish feats that other violinists would deem impossible. 

• The chapter about post-mortem diagnosis of historical figures is quite good. There were lots of great stories about the possible genetic disorders of Toulouse-Lautrec, King Tut, and Abraham Lincoln. I had never heard before that John F. Kennedy had Addison's Disease, a condition of the adrenal glands that depletes the body of cortisol. One common side effect of Addison's is the bronze skin, which served JFK well in his debate against the pasty Dick Nixon in 1960.  

Of course, there were lots of these interesting tidbits peppered throughout the book. Overall, the book was organized in an interesting and logical way. I like that Kean is about telling the story of science with the scientists being the main characters and the results being the major plot points.